Endometrial PRP/PRGF
What is endometrial PRP / PRGF therapy
PRP (Platelet Rich Plasma) therapy is a method used in reproductive medicine with the aim of supporting the development and functionality of the endometrium. PRP is derived from the woman’s own blood, which undergoes special laboratory processing so that platelet-rich plasma can be isolated.
In the context of assisted reproduction, the processed plasma can be injected into the uterus with the aim of supporting the development of the endometrium before embryo transfer.
PRGF (Plasma Rich in Growth Factors) is an advanced form of PRP therapy, in which the plasma undergoes additional processing in order to achieve a higher concentration of growth factors associated with the tissue regeneration process.
The role of the endometrium in embryo implantation
Proper development and functionality of the endometrium are considered important factors for successful embryo implantation and the progression of a pregnancy.
During the menstrual cycle, the endometrium changes under the influence of hormones and is prepared to become receptive to embryo implantation. In order to be considered suitable for embryo transfer, the endometrium must have sufficient thickness and good blood supply.
How PRP / PRGF therapy may help the endometrium
The growth factors contained in platelet-rich plasma participate in biological mechanisms associated with tissue regeneration and improved blood supply.
In the context of assisted reproduction, the application of this method may, in certain cases, contribute to creating more favorable conditions for embryo implantation.
Improvement of endometrial thickness
In women with a thin endometrium, PRP / PRGF therapy may be considered as a method that may support the growth of endometrial tissue. In some cases, an increase in endometrial thickness has been observed after the treatment is applied.
Support of endometrial receptivity
Endometrial receptivity refers to its ability to receive and support embryo implantation. The growth factors contained in PRP are considered capable of influencing mechanisms related to the functionality of endometrial tissue.
Improvement of implantation conditions
By improving certain characteristics of the endometrium, such as blood supply and cellular activity, the therapy may in some cases contribute to creating more favorable conditions for embryo implantation before embryo transfer.
How does it work?
PRP/PRGF therapy is a relatively simple procedure that takes only a short time and usually does not require anesthesia or hospitalization. It involves the following basic steps:
Blood collection and plasma preparation
The procedure begins with the collection of a small amount of blood from the patient, similar to a routine blood draw. The sample is sent to the laboratory, where it undergoes a special process to separate the plasma from the other blood components.
Laboratory processing
In the laboratory, the blood is centrifuged to isolate the platelet-rich plasma. Platelets contain growth factors and other biological substances associated with tissue healing and regeneration mechanisms. In the case of the PRGF technique, additional processing is applied to increase the concentration of growth factors.
Intrauterine injection of PRP / PRGF
After the plasma has been prepared, the PRP/PRGF is injected into the uterus using a thin catheter, in a procedure similar to that of embryo transfer. The procedure is brief and is usually well tolerated by patients, and the woman can return to her daily activities immediately.
In some cases, two or more injections may be required.
Follow-up after infusion therapy
Following treatment, a period of medical monitoring is conducted to assess the endometrial response. This monitoring is usually performed via ultrasound to evaluate the growth and thickness of the endometrium.
In some cases, endometrial thickness measurements may be repeated during the cycle, particularly when treatment is administered as part of preparation for embryo transfer. This evaluation helps assess whether the endometrium is responding to the treatments being administered.
Depending on the findings and the overall treatment plan, the physician may proceed with scheduling the embryo transfer or recommend further monitoring and adjustment of the treatment.
In which cases may endometrial PRP / PRGF therapy be recommended
PRP / PRGF therapy may be considered in certain cases, such as the following:
Thin endometrium
In some women, endometrial thickness may remain low even after hormonal therapy. In these cases, PRP / PRGF therapy may be considered as a possible method to support endometrial growth before embryo transfer.
Repeated implantation failure
The therapy may also be considered in cases of repeated failed implantations after embryo transfer, when no other clear factors are identified to explain the failure.
Chronic inflammation of the endometrium
In some cases, the presence of chronic inflammation in the endometrium may affect its receptivity and make embryo implantation more difficult. PRP / PRGF therapy is being investigated as a possible method to support the restoration of endometrial tissue.
Asherman syndrome
Asherman syndrome is characterized by the presence of adhesions inside the uterus, which may affect the normal development of the endometrium. In some cases, PRP / PRGF therapy may be considered as part of the overall management of the condition.
Frequently asked questions (FAQ)
The procedure is usually brief and well tolerated. The injection is performed with a thin catheter, similar to the embryo transfer procedure, and in most cases anesthesia is not required.
The treatment is usually applied before embryo transfer, as part of endometrial preparation.
The overall procedure, from blood collection to plasma injection, usually takes a few minutes.
The treatment uses plasma derived from the patient’s own blood, which significantly reduces the risk of allergic reactions or immune rejection.
The cost of the treatment may vary depending on the treatment plan and the protocol applied. For this reason, an accurate cost estimate is provided after medical evaluation.
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