NIKA Biopsy
The NIKA Biopsy is a specialized endometrial biopsy used in the investigation of recurrent implantation failure, unexplained infertility, and miscarriage.
When the standard evaluation (hormonal testing, ultrasound, hysteroscopy) is normal but pregnancy is still not achieved, the possibility that the issue involves the endometrium—that is, the implantation environment—is considered.
The examination aims at the direct assessment of endometrial architecture under high-resolution electron microscopy, as well as the identification of microbial and inflammatory factors that may affect uterine receptivity.
It is not a routine test. It is part of a specialized fertility evaluation.
What is the NIKA test?
It involves taking a small sample of endometrial tissue, which is sent for microbiological and histological analysis (high-resolution electron microscopy).
The assessment is performed directly on uterine tissue—not on vaginal fluid—which allows for more accurate detection of:
- pathogenic microorganisms
- chronic endometritis
- inflammatory changes
- scar tissue
These abnormalities are often not visible on ultrasound and may not be accompanied by symptoms.
How is the test performed?
The procedure is performed in the clinic.
Using a thin catheter inserted through the cervix, a small sample is taken from the endometrium. No incision or general anesthesia is required. The procedure lasts a few minutes, and any discomfort is usually mild, similar to menstrual cramps.
Timing is determined at a specific phase of the cycle, according to the treatment plan.
NIKA Biopsy and IVF failure
In cases of recurrent embryo transfer failure, especially when the embryos are of good quality, the endometrium is assessed as a possible limiting factor.
Implantation requires an endometrium free of active inflammation and with a normal microbial balance. A subclinical infection or chronic endometritis may negatively affect the process without causing obvious clinical signs.
The NIKA Biopsy helps identify these conditions so that, if needed, targeted treatment can be given before a new IVF attempt.
When is it recommended?
The test is considered in cases of:
- recurrent implantation failure
- unexplained infertility
- recurrent miscarriage
- suspected chronic endometritis
The decision is made on an individual basis, according to the medical history and previous treatments.
Frequently Asked Questions (FAQ)
The test itself does not increase success rates. However, if an underlying inflammation or infection is identified and treated, implantation conditions may improve before a new embryo transfer.
The test may cause mild discomfort, similar to menstrual cramps, lasting a few minutes. General anesthesia is not required, and most women return to their activities immediately.
Timing is determined by the physician, usually during a specific phase of the cycle, so that the sample is suitable for reliable evaluation. Exact scheduling depends on the treatment plan.
If pathogenic microorganisms or signs of chronic inflammation are detected, targeted antibiotic treatment is prescribed (often in the form of intrauterine infusions). After treatment is completed, repeat testing may be recommended before a new embryo transfer.
No. Although all these tests concern the investigation of the endometrium, they differ in methodology and in the markers they assess. The choice of the appropriate test is made individually, according to the patient’s history and previous failures.
The decision depends on the results. If no pathological finding is identified, a new cycle may be scheduled according to the physician’s plan. If treatment is required, it must be completed first.
The test is usually performed as a private expense. The physician can provide detailed information about the cost and available options.
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